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New Report on Temporomandibular Disorders: Priorities for Research and Care

Over a year and half ago, the National Academy of Medicine (NAM) began the most comprehensive study ever undertaken on Temporomandibular Disorders (TMD). The study assessed the current state of TMD research, education and training, the safety and efficacy of clinical treatments, and associated burden and costs.

Statement by NIDCR Acting Director on the National Academies of Sciences, Engineering, and Medicine Report on Temporomandibular Joint Disorders

I am pleased to announce the release of the National Academies of Sciences, Engineering, and Medicine (NASEM) report, Temporomandibular Disorders: Priorities for Research and Care. As underscored by the comprehensive report, temporomandibular joint disorders (TMJDs) are a diverse and still poorly understood set of complex, painful conditions affecting the jaw muscles and tissues, temporomandibular joints, and associated nerves. Clearly, there is much more to be understood, and these conditions continue to confound medical and dental health care providers and researchers.

Have you seen the film Dark Waters?

The Film. Dark Waters is about attorney Robert Billott's real-life 20 year legal battle against DuPont chemical for releasing toxic waste - perfluorooctanoic acid, or PFOA - into Parkersburg, West Virginia's water supply, with devastating health effects on the townspeople and livestock. PFOA, also known as C8, is a man-made chemical. It is used in the process of making Teflon and similar chemicals known as fluorotelomers.

Online TMD Diet Diary Research Project

Online TMD Diet Diary Research Project The TMJ Association received the following request from Professor Justin Durham and his research team at Newcastle University. We encourage TMJ patients to participate in this project as it is an under researched

Drug Induced Bruxism

The authors of this article state that orofacial movement disorders (bruxism) are treated typically by dental professionals and not by those specialists (neurologists) researching and treating the other movement disorders (Parkinson's disease, Huntington's disease, tremors, etc.). Again, this is more evidence of the complexity of TMD and the need for multidisciplinary research and treatment in TMD.

More on the Role of Estrogens in TMD

  • Dec 26, 2013

That TMD predominantly strikes women in their childbearing years has long intrigued scientists. But studies of the effects of female hormones—exactly how they affect TMD symptoms—remain controversial.

Now scientists in China, in an experiment on female rats with inflamed jaws, suggest that estradiol (the most potent of naturally occurring estrogens in mammals) increases pain sensitivity. It does this by stimulating nerve cells in a part of the brain called the hippocampus to express a specific type of “vanilloid” receptor that responds to pain associated with acid, hot peppers, and heat (including the heat associated with inflammation). This expression of vanilloid receptors amplifies the pain signals coming into the brain from nerves in the inflamed jaws.

The studies involved female rats whose jaws had become painfully inflamed as a result of a chemical injection. The ovaries of the rats had been surgically removed (ovariectomy), but the rats were then given varying doses of replacement estradiol. Compared to a control group of ovariectomized rats without replacement hormones, the estradiol rats proved more sensitive to normally painless pressures applied to the jaw, which they showed by quickly withdrawing their heads to mild pressures. As a further confirmation of their conclusions, the experimenters injected a substance into the hippocampus that blocked the actions of the vanilloid receptors and showed that it significantly reduced the rat’s sensitivity to mild pressures.

17-β-Estradiol Enhanced Allodynia of Inflammatory Temporomandibular Joint through Upregulation of Hippocampal TRPV1 in Ovariectomized Rats

TMJ Disorders


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