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The TMJ Association is pleased to partner with Inspire to bring you the TMJ Cafe, a free online support network and discussion community for those with Temporomandibular Disorders (TMD). We invite you to meet others like you, share experiences and tips for getting through the day, and give and receive support.

Sustained and Repeated Mouth Opening Leads to Development of Painful Temporomandibular Disorders Involving Macrophage/Microglia Activation in Mice

Temporomandibular disorder (TMD) is a set of heterogeneous musculoskeletal conditions involving the temporomandibular joint (TMJ) and/or the masticatory muscles. Up to 33% of the population has had at least one symptom of TMD with 5-10% of them requiring treatment. Common symptoms include limited jaw movement, joint sound, and pain in the orofacial area. Once TMD becomes chronic, it can be debilitating with comorbidities that greatly reduce one's overall quality of life. However, the underlying mechanism of TMD is unclear due to the multicausative nature of the disease.

Prevalence of TMD in Sjӧgren Syndrome Patients

Sjӧgren's Syndrome seems to play a role in temporomandibular joint disorders.

Early Molecular Response and Microanatomical Changes in the Masseter Muscle and Mandibular Head After Botulinum Toxin Intervention in Adult Mice

The Botox-injected masseters had greatly increased expression of genes involved in muscle atrophy at the 1 week time point compared to the control side muscles. At the end of the study, 2 weeks after injection, the Botox-injected masseters were about 20% smaller than the control side masseters, and the Botox-side condyles had lost about 40% of relative bone area compared to the control side condyles.

Centralized Pain in TMD: Is It All in the Head?

We are pleased to introduce Sophia Stone, a new contributor to The TMJ Association, whose passion is to separate TMD fact from TMD fiction. Sophia has a background in medicine and research and can draw on her personal experience as a TMD patient.

John: The Importance of Education

  • May 13, 2015

John is a former Professor of Finance at American University in Washington D.C. He is married and has three children. The unpredictable nature of his TMJ symptoms put a strain on his family. In the Fall of 2001, John began to seek relief from TMJ pain–ultimately spending well over $10,000 on treatments that were ineffective.

Finally, in January 2005, he was diagnosed with Lyme disease, a tick-borne infection that caused TMJ issues. The antibiotic protocols which were prescribed to treat the Lyme disease alleviated John’s TMJ problems. As a result of his experience with a systemic illness, John has become a strong advocate for medical research.

John Benjamin wrote: “In my quest for answers, I have gained great insight into the lack of science underlying TMJ treatments as well as the lack of understanding of these conditions. Interdisciplinary research is desperately needed to understand what today we call “TMJ.” I regret that I endured years of suffering, needless dental treatments, and spent thousands of dollars only to learn that I had a systemic underlying illness that caused my TMJ problems. If it had not been for The TMJ Association, I would have had TMJ surgery—a surgery I didn’t need, that would not have addressed the causes of the jaw pain, and which could have caused me more harm.

The TMJ Association is the leading resource for information on TMJ diseases and disorders. Through our publications, educational meetings, and patient support network, the Association reaches out to people, such as John, and provides them guidance in making their health care decisions. The needs and concerns of TMJ patients shape the Association’s daily activities and mission.

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