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The TMJ Association is pleased to partner with Inspire to bring you the TMJ Cafe, a free online support network and discussion community for those with Temporomandibular Disorders (TMD). We invite you to meet others like you, share experiences and tips for getting through the day, and give and receive support.

Sustained and Repeated Mouth Opening Leads to Development of Painful Temporomandibular Disorders Involving Macrophage/Microglia Activation in Mice

Temporomandibular disorder (TMD) is a set of heterogeneous musculoskeletal conditions involving the temporomandibular joint (TMJ) and/or the masticatory muscles. Up to 33% of the population has had at least one symptom of TMD with 5-10% of them requiring treatment. Common symptoms include limited jaw movement, joint sound, and pain in the orofacial area. Once TMD becomes chronic, it can be debilitating with comorbidities that greatly reduce one's overall quality of life. However, the underlying mechanism of TMD is unclear due to the multicausative nature of the disease.

Prevalence of TMD in Sjӧgren Syndrome Patients

Sjӧgren's Syndrome seems to play a role in temporomandibular joint disorders.

Early Molecular Response and Microanatomical Changes in the Masseter Muscle and Mandibular Head After Botulinum Toxin Intervention in Adult Mice

The Botox-injected masseters had greatly increased expression of genes involved in muscle atrophy at the 1 week time point compared to the control side muscles. At the end of the study, 2 weeks after injection, the Botox-injected masseters were about 20% smaller than the control side masseters, and the Botox-side condyles had lost about 40% of relative bone area compared to the control side condyles.

Centralized Pain in TMD: Is It All in the Head?

We are pleased to introduce Sophia Stone, a new contributor to The TMJ Association, whose passion is to separate TMD fact from TMD fiction. Sophia has a background in medicine and research and can draw on her personal experience as a TMD patient.

Patients in Los Angeles or New York City Needed for Clinical Study - Comparative Study of Women Considering or Currently Receiving Botox© Injections for TMJ Pain

  • Jan 17, 2018

Are you a woman with "TMJ" pain in facial muscles, who has either:

a. recently had Botox© injections for your pain or

b. not had Botox© for your pain but has thought about such treatment?

If either is true for you, you may qualify for an observational research study centrally administered by the NYU College of Dentistry. It is funded by the National Institutes of Health (NIH). The purpose of this study is to understand potential health risks that may be caused by treating "TMJ pain" with Botox© injections.

Potentially eligible women must first complete a brief interview via telephone to confirm eligibility.

Study participation involves:

  • By telephone, completion of a full informed consent process with one of our research staff;
  • Completion of a medical release form to obtain TMJ-related treatment records;
  • Completion of a web-based survey about your treatment experience;
  • Imaging of your facial bones using relatively low-radiation “Cone Beam Computed Tomography” (CBCT), and
  • DEXA bone density scans to check your overall bone density. Imaging procedures may be scheduled on the same day or different days;
  • Participants receive $400 for time, effort and transportation costs.

Eligible women must:

  • Live in the Los Angeles or New York City metropolitan area, or be willing/able to travel to either area for imaging appointments;
  • Be over age 18;
  • Have sought care for ”TMJ” pain within the last 6 months;
  • Have had “TMJ” pain for at least one year;
  • Have either:
    • o Within the last 9 months, received 2+Botox© treatments with injections to the cheek muscle(s),
    • OR never received Botox© for any reason but have received other partly effective facial pain treatments from a dentist or physician.

Click here to view a full copy of the consent form, describing the study in detail.

For further information or to request screening eligibility, please contact a member of the NYU research staff by phone at (212) 998-9208 or by email: dentalbotox@nyu.edu

TMJ Disorders

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